Ponepal V, Spielberger U, Riedel-Caspari G, Schmidt F W
Tierärztliches Institut, Universität Göttingen.
Dtsch Tierarztl Wochenschr. 1996 Oct;103(10):390-4.
Two studies have been carried out to evaluate the prophylactic and therapeutical effect of a 30%-extract from the coffee-bean seeds Coffeae arabicae on infectious diseases in newborn calves. 1. Within a large cattle-herd, which endemically showed a high proportion of infections within the gastroenteric and/or respiratory systems in calves, a randomised placebo-controlled double-blind study has been done. 50 newborn calves were given a subcutaneous injection of 10 ml Coffea-preparation 30% on first and third day of life. Another 50 calves received physiological saline as control. An index was set up which allowed to daily evaluate and compare body-temperature, consistency of feces, exsiccation-degree and breathing-rate of the animals. Besides this the number of therapeutical interventions and the number of days with disease-symptoms were recorded. Calves treated with Coffea-extract showed: on first and second day of life less animals with body-temperature below physiological values (p < 0.001 or 0.1 resp.), during the first period of diarrhea (between fourth and sixth day) significantly lower tendency of diarrhea (p < 0.1; 0.001; 0.005 resp.), after the second period of diarrhea (around the 9th day of life) a better and quicker recovery and a lower tendency of exsiccation (p < 0.05 on day 10 and 11) as the control-calves. Besides this the average duration of illness was shorter (4.7 instead of 7 days) and the average number of therapeutical interventions were less (3.1 instead of 4.5) than in control-calves. 2. Within four cattle-herds endemically showing a high rate of diarrhea in newborn calves the morbidity in a total of 371 animals could be dropped from about 45% to 10% by prophylactic administration of one to three s.-c.-injections of 10 ml Coffea-preparation together with one or two million i.U.Vit.A. one time perorally. For prophylactic use two injections of coffea preparation. on day 1 and 4 of life proved to be efficient under the given circumstances. Therapeutically the daily administration of a combination of Coffea-extract together with oral drugs containing tannic substances and diet-feed could reduce the mortality in animals with acute disease to about 30%.
已开展两项研究，以评估咖啡豆种子阿拉伯咖啡30%提取物对新生犊牛传染病的预防和治疗效果。1. 在一个大型牛群中，犊牛胃肠道和/或呼吸系统感染比例普遍较高，在此牛群中进行了一项随机安慰剂对照双盲研究。50头新生犊牛在出生第一天和第三天皮下注射10毫升30%的咖啡制剂。另外50头犊牛接受生理盐水作为对照。设立了一个指标，以便每天评估和比较动物的体温、粪便稠度、脱水程度和呼吸频率。除此之外，记录治疗干预的次数和出现疾病症状的天数。用咖啡提取物治疗的犊牛表现为：出生第一天和第二天体温低于生理值的动物较少（分别为p<0.001或0.1），在腹泻第一阶段（第四天至第六天之间）腹泻倾向明显较低（分别为p<0.1；0.001；0.005），在腹泻第二阶段之后（出生后第9天左右），与对照犊牛相比恢复更好、更快，脱水倾向更低（第10天和第11天p<0.05）。除此之外，疾病的平均持续时间更短（4.7天而非7天），治疗干预的平均次数比对照犊牛少（3.1次而非4.5次）。2. 在四个新生犊牛腹泻率普遍较高的牛群中，通过预防性皮下注射一至三次10毫升咖啡制剂以及口服一至两百万国际单位维生素A，总共371头动物的发病率可从约45%降至10%。在给定情况下，出生第一天和第四天进行两次咖啡制剂注射预防有效。在治疗方面，每天联合使用咖啡提取物与含单宁物质的口服药物以及饲料可将急性病动物的死亡率降低至约30%。
