Kirpatovskiĭ V I, Ianenko E K, Kazachenko A V, Golovanov S A, Kovalenko E A, Borisik V I
Urol Nefrol (Mosk). 1996 Nov-Dec(6):16-9.
Continuous 40-min ischemia and ischemia with reperfusion (10 min of ischemia and 10 min of reperfusion) induced by ligation of the vascular kidney crus were compared in experiments on 17 New Zealand rabbits. Both in continuous and interrupted (in period 4) ischemia resulted in the growth of pO2 cortical layer which is likely to be due to reduced oxygen utilization of the cells caused by metabolic and renal function disorders. Examination of lipid peroxidation activity determined similar activation of this process in both ischemic variants. In spite of the fact that both continuous and interrupted ischemias induced similar hyperoxygenation of the cortical substance and the same activation of lipid peroxidation, functional damage was less severe in experiments with interrupted ischemia.
在17只新西兰兔身上进行的实验中，比较了通过结扎肾血管蒂诱导的持续40分钟缺血以及缺血再灌注（10分钟缺血和10分钟再灌注）的情况。在持续缺血和间歇性（第4阶段）缺血中，皮质层的pO2均升高，这可能是由于代谢和肾功能紊乱导致细胞对氧气的利用减少所致。对脂质过氧化活性的检测表明，在两种缺血变体中该过程的激活情况相似。尽管持续缺血和间歇性缺血均诱导了皮质物质相似的高氧状态以及脂质过氧化的相同激活，但间歇性缺血实验中的功能损伤较轻。
