[The role of detrusor hypoxia in the pathogenesis of urination disorders in patients with benign prostatic hyperplasia].

The aim of the study was to clarify the role of hypoxia of detrusor as a component of aging in establishment of urination disorders in patients with benign prostatic hyperplasia (BPH). A total of 54 patients were examined. Whether the capacity of detrusor to absorb oxygen was affected or not was judged by the difference in oxygen tension and acid-base balance in blood samples obtained intraoperatively from a radialis, v. mediana cubiti, v. vesicalis in 30 patients (experimental group) versus control values (5 females operated for stenosis of the distal ureter, ureterovaginal fistulas). The findings provided evidence for marked hypoxia of the detrusor diminishing reservoir function of the bladder and promoting urination disorders. A course of hyperbaric oxygenation given to 17 BPH patients has improved the capacity of the bladder for urine accumulation, reduced pollakiuria, especially at night. This supports involvement of detrusor hypoxia in pathogenesis of urination disorders in BPH patients.