Sonenshein G E
Department of Biochemistry, Boston University School of Medicine, MA 02118, USA.
J Immunol. 1997 Mar 1;158(5):1994-7.
Whereas overexpression of the c-myc gene was found to promote apoptosis in fibroblasts, myeloid, and T cells, physiologic cell death of immature B cell lymphomas correlated with a drop in c-myc expression. Here, the author reviews recent evidence demonstrating that inhibition of c-myc expression activates apoptosis of B cell models of clonal deletion and that rescue from apoptosis by CD40 ligand leads to maintenance of c-Myc levels. A model of differential functional expression of the c-myc gene is discussed.
虽然发现c-myc基因的过表达可促进成纤维细胞、髓样细胞和T细胞的凋亡，但未成熟B细胞淋巴瘤的生理性细胞死亡与c-myc表达的下降相关。在此，作者回顾了最近的证据，这些证据表明抑制c-myc表达可激活克隆缺失的B细胞模型的凋亡，并且通过CD40配体从凋亡中挽救可导致c-Myc水平的维持。本文讨论了c-myc基因的差异功能表达模型。
