Mercer J G, Moar K M, Rayner D V, Trayhurn P, Hoggard N
Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen, UK.
FEBS Lett. 1997 Feb 3;402(2-3):185-8. doi: 10.1016/s0014-5793(96)01525-6.
Leptin receptor gene expression has been measured in arcuate and ventromedial hypothalamic nuclei. Receptor mRNA in both hypothalamic areas was higher in obese mice than in lean littermates. Twice daily leptin administration for 7 days profoundly affected food intake, reduced leptin receptor mRNA in the arcuate nucleus, and had a similar effect on neuropeptide Y gene expression. A single leptin injection was ineffective. Exposure of lean mice to cold for 24 h caused an induction of leptin receptor and NPY mRNA which was normalized when animals were returned to the warm. Regulation of receptor gene expression may be an important component in the reading of the leptin signal.
已对弓状核和腹内侧下丘脑核中的瘦素受体基因表达进行了测定。肥胖小鼠这两个下丘脑区域中的受体mRNA水平高于其瘦的同窝小鼠。每天两次注射瘦素，持续7天，可显著影响食物摄入量，降低弓状核中的瘦素受体mRNA水平，并且对神经肽Y基因表达有类似影响。单次注射瘦素则无效。将瘦小鼠暴露于寒冷环境24小时会导致瘦素受体和神经肽Y mRNA的诱导，当动物回到温暖环境时这种诱导作用恢复正常。受体基因表达的调节可能是解读瘦素信号的一个重要组成部分。
