Kawaguchi K, Simon R P
Department of Neurology, University of Pittsburgh, PA 15213, USA.
Brain Res. 1997 Jan 23;746(1-2):59-62. doi: 10.1016/s0006-8993(96)01096-7.
Deep prepiriform cortex modulates excitatory activity in the limbic system during seizures. We therefore studied a potential role for this system in another process involving excitatory neurotransmission: global ischemia in the rat. The non-NMDA antagonist NBQX was microinjected bilaterally into deep prepiriform cortex prior to 10 min of global ischemia. Hippocampal cell injury was then assessed by heath shock protein (HSP) expression 24 h after ischemia. NBQX significantly decreased the number of HSP positive cells in both CA1 and CA3 hippocampal subsectors, suggesting the possibility that pathways from deep prepiriform cortex to hippocampus modulate excitotoxicity in target neurons during ischemia.
在癫痫发作期间，梨状皮质深层调节边缘系统中的兴奋性活动。因此，我们研究了该系统在另一个涉及兴奋性神经传递的过程中的潜在作用：大鼠全脑缺血。在全脑缺血10分钟之前，将非NMDA拮抗剂NBQX双侧微量注射到梨状皮质深层。然后在缺血24小时后通过热休克蛋白（HSP）表达评估海马细胞损伤。NBQX显著减少了海马CA1和CA3亚区中HSP阳性细胞的数量，这表明从梨状皮质深层到海马的通路在缺血期间可能调节靶神经元中的兴奋性毒性。
