Kawaguchi K, Simon R P
Department of Neurology, University of Pittsburgh, Pennsylvania 15213, USA.
J Cereb Blood Flow Metab. 1997 Mar;17(3):356-60. doi: 10.1097/00004647-199703000-00012.
Deep prepiriform cortex has an important role in modulating neurotransmission during limbic seizures. We used pharmacologic blockade of non-N-methyl-D-aspartate (NMDA) receptors to study excitatory circuitry from the deep prepiriform cortex to the hippocampus during global ischemia in rat. NBQX, a potent non-NMDA glutamate receptor antagonist, was microinjected stereotactically into the deep prepiriform cortex before global ischemia for 10 min. Neuronal cell death in the hippocampus was evaluated quantitatively 72 h after ischemia. The NBQX-injected rats had a greater number of surviving cells in CA1 sector of hippocampus than did saline-injected controls or rats that received NBQX injections 1 mm from the target. Thus, excitatory amino acid-mediated circuitry emanating from deep prepiriform cortex modulates ischemic neuronal injury in the hippocampus.
梨状皮质深层在边缘系统癫痫发作期间调节神经传递方面发挥着重要作用。我们使用非N-甲基-D-天冬氨酸（NMDA）受体的药理学阻断来研究大鼠全脑缺血期间从梨状皮质深层到海马的兴奋性神经回路。强效非NMDA谷氨酸受体拮抗剂NBQX在全脑缺血前10分钟通过立体定向微量注射到梨状皮质深层。缺血72小时后定量评估海马中的神经元细胞死亡情况。注射NBQX的大鼠海马CA1区存活细胞数量比注射生理盐水的对照组或在距靶点1毫米处注射NBQX的大鼠更多。因此，源自梨状皮质深层的兴奋性氨基酸介导的神经回路调节海马中的缺血性神经元损伤。
