Mawle A C
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Immunol Invest. 1997 Jan-Feb;26(1-2):269-73. doi: 10.3109/08820139709048932.
Chronic fatigue syndrome (CFS) has emerged as a public health concern over the past decade. A working case definition was created in 1988 and revised in 1994, and this has been used to establish prevalence estimates using physician-based surveillance and an a random digit dial telephone survey. Although CFS has some characteristics of an infectious disease, so far no infectious agent has been associated with the illness. Studies of immune function in CFS patients failed to detect differences between cases and healthy controls. However, when cases were subgrouped according to whether they had a sudden or gradual onset, differences in immunologic markers were detected between cases and their matched controls.
在过去十年中，慢性疲劳综合征（CFS）已成为一个公共卫生问题。1988年制定了一个现行病例定义，并于1994年进行了修订，该定义已被用于通过基于医生的监测和随机数字拨号电话调查来确定患病率估计值。尽管CFS具有一些传染病的特征，但迄今为止尚未发现有任何感染因子与该疾病相关。对CFS患者免疫功能的研究未能检测到病例组与健康对照组之间的差异。然而，当根据起病是突然还是逐渐进行病例分组时，在病例组与其匹配的对照组之间检测到了免疫标志物的差异。
