Zhang Q W, Natelson B H, Ottenweller J E, Servatius R J, Nelson J J, De Luca J, Tiersky L, Lange G
Department of Neurosciences, University of Medicine and Dentistry-New Jersey Medical School, Newark, USA.
Chronobiol Int. 2000 Jan;17(1):95-9. doi: 10.1081/cbi-100101035.
The fact that many patients with chronic fatigue syndrome (CFS) have an infectious like sudden onset to their illness has led to the hypothesis that CFS is a medical illness. If CFS were, on the other hand, a psychiatric disorder related to symptom amplification, one would expect illness onset to occur randomly over the calendar year. This study tested that hypothesis with 69 CFS patients whose illness was on the more severe side of the illness spectrum; all patients reported sudden illness onset with the full syndrome of sore throat, fatigue/malaise, and diffuse achiness developing over no longer than a 2-day period. Date of illness onset was distinctly nonrandom. It peaked from November through January and was at its lowest from April through May. These data support the hypothesis that an infectious illness can trigger the onset of CFS.
许多慢性疲劳综合征（CFS）患者发病时类似感染性疾病那样突然发作，这一事实引发了关于CFS是一种医学疾病的假说。另一方面，如果CFS是一种与症状放大相关的精神疾病，那么人们会预期发病在一整年中随机发生。本研究对69名病情处于疾病谱较严重一端的CFS患者进行了该假说的检验；所有患者均报告疾病突然发作，且在不超过2天的时间内出现了喉咙痛、疲劳/不适和全身酸痛的完整综合征。发病日期明显不是随机的。发病高峰期为11月至1月，而4月至5月则处于最低水平。这些数据支持了感染性疾病可引发CFS发病的假说。
