核苷5'-烷基磷酸酯对酿酒酵母有性凝集的抑制作用。

Inhibitory effects of nucleoside 5'-alkylphosphates on sexual agglutination in Saccharomyces cerevisiae.

作者信息

Machida K, Tanaka T, Shibata K, Taniguchi M

机构信息

Faculty of Science, Osaka City University, Japan.

出版信息

FEMS Microbiol Lett. 1997 Feb 1;147(1):17-22. doi: 10.1111/j.1574-6968.1997.tb10214.x.

DOI:10.1111/j.1574-6968.1997.tb10214.x

PMID:9037758

Abstract

Among various nucleoside 5'-alkylphosphates, uridine 5'-hexadecylphosphate (UMPC16) and adenosine 5'-hexadecylphosphate (AMPC16) inhibited the sexual agglutination between a and alpha haploid cells of Saccharomyces cerevisiae. The effect of AMPC16 accompanied severe growth inhibition of the yeast cells but it was not observed with UMPC16. Sexual agglutination was not inhibited by the presence of UMPC16 or AMPC16 when the yeast cells had been pretreated with the mating pheromone. UMPC16 was characterized as a specific inhibitor of sexual agglutination without direct influence on the agglutinin function, being distinguishable from any of those ever known.

摘要

在各种核苷5'-烷基磷酸酯中，尿苷5'-十六烷基磷酸酯（UMPC16）和腺苷5'-十六烷基磷酸酯（AMPC16）可抑制酿酒酵母a型和α型单倍体细胞之间的性凝集。AMPC16的作用伴随着酵母细胞的严重生长抑制，但UMPC16未观察到这种情况。当酵母细胞用交配信息素预处理时，UMPC16或AMPC16的存在不会抑制性凝集。UMPC16被表征为性凝集的特异性抑制剂，对凝集素功能无直接影响，与任何已知的抑制剂都不同。