Shaw S W, Johnson R H, Keogh H J
J Neurol Sci. 1977 Aug;33(1-2):51-9. doi: 10.1016/0022-510x(77)90181-2.
(1) Intravenous glucose tolerance tests have been carried out on 6 migraine sufferers on two occasions. The first study was carried out during a migraine attack and the second was performed in an attack-free period. The patients had fasted overnight and the investigations were carried out in the morning. Samples of venous blood were taken for measurement of concentrations of glucose, lactate, pyruvate, free fatty acids (FFA), glycerol, ketone-bodies, insulin and growth hormone. (2) an impaired tolerance to glucose was found during the migraine attacks compared with the control studies. Elevated ketone and FFA levels were found during the attacks and may have accounted for the glucose intolerance. The elevation of plasma FFA levels during the migraine attacks paralleled changes in blood glycerol concentrations suggesting increased lipolysis during the attacks. Growth hormone and cortisol were raised and insulin was depressed during attacks. (3) Our observations, in which the patients acted as their own controls, imply increased lipolysis during migraine attacks and are in contrast to previously reported studies. The patterns of metabolic and hormonal changes are consistent with a stress response during the attacks and the significance in relation to the causation of the attacks is discussed.
(1) 对6名偏头痛患者进行了两次静脉葡萄糖耐量试验。首次研究在偏头痛发作期间进行，第二次在无发作期进行。患者已禁食过夜，检查于上午进行。采集静脉血样本以测量葡萄糖、乳酸、丙酮酸、游离脂肪酸（FFA）、甘油、酮体、胰岛素和生长激素的浓度。(2) 与对照研究相比，在偏头痛发作期间发现葡萄糖耐量受损。发作期间发现酮体和FFA水平升高，这可能是葡萄糖不耐受的原因。偏头痛发作期间血浆FFA水平的升高与血液甘油浓度的变化平行，表明发作期间脂解增加。发作期间生长激素和皮质醇升高，胰岛素降低。(3) 我们的观察结果，即患者以自身作为对照，表明偏头痛发作期间脂解增加，这与先前报道的研究相反。代谢和激素变化模式与发作期间的应激反应一致，并讨论了其与发作病因的关系。
