Yamawaki T, Shimizu Y, Hasumi K
Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan.
Gynecol Oncol. 1997 Feb;64(2):265-9. doi: 10.1006/gyno.1996.4537.
A 46-year-old woman with stage IV "high-grade" endometrial stromal sarcoma presented with massive uterine bleeding and dyspnea. Her WHO performance status was grade 4. After chemotherapy consisting of ifosfamide, Adriamycin, and cisplatin, the uterus shrank from 20 x 15 x 15 to 6 x 6 x 8 cm and multiple pulmonary nodules almost completely disappeared. The PO2 increased from 57.8 to 89.3 mmHg and her performance status improved to grade 0, making it possible for pelvic surgery to be performed. At 10 months postoperatively, there was no evidence of disease. This case suggests that IAP might be effective chemotherapy for patients with high-grade endometrial stromal sarcoma.
一名46岁患有IV期“高级别”子宫内膜间质肉瘤的女性出现大量子宫出血和呼吸困难。她的世界卫生组织体能状态为4级。在接受由异环磷酰胺、阿霉素和顺铂组成的化疗后，子宫从20×15×15厘米缩小至6×6×8厘米，多个肺结节几乎完全消失。动脉血氧分压从57.8毫米汞柱升至89.3毫米汞柱，她的体能状态改善至0级，使得盆腔手术得以进行。术后10个月，无疾病迹象。该病例表明异环磷酰胺、阿霉素和顺铂联合化疗可能对高级别子宫内膜间质肉瘤患者有效。
