A strain specific increase in blood glycerol level of the carbohydrate-sensitive BHE rat.

A strain-specific, elevated serum free glycerol has been found in stock diet fed, carbohydrate-sensitive, hyperlipemic BHE rats. This suggests that considerably more peripheral lipolysis is taking place in the nonfasting BHE rat than in its Wistar counterpart. This observation further suggests that the BHE rat may exhibit metabolic changes in the fed state that are similar to those found in normal fasting rats. Individual, serum free glycerol levels were not correlated with individual serum insulin values. In the nonfasted BHE rats, serum free glycerol concentrations were found to be sufficiently high to initiate gluconeogenesis or to contribute to a maximal rate of triglyceride synthesis.