Zhu N, Warr R, Cai R, Rigby H S, Burd D A
Department of Plastic Surgery, Frenchay Hospital, UK.
Br J Plast Surg. 1997 Jan;50(1):10-4. doi: 10.1016/s0007-1226(97)91276-5.
Between the years 1967 and 1993, 3246 patients were diagnosed with malignant melanoma at Frenchay Hospital, Bristol. This paper reports 47 patients, 21 years of age or under, including 10 preadolescent cases under 14 years of age. It represents a further follow-up of a cohort originally published from this centre in 1986 in addition to 18 new cases. Most (89%) of the lesions occurred on the trunk and extremities, with females showing a predominance of lesions on the lower limbs. 83% of the melanomas were of the superficial spreading type: 72% invaded to Clark level III and IV. Thickness ranged from 0.29 mm to 50.00 mm (median 1.20 mm). Ulceration was present in 17% of cases and 32% of melanomas arose within a pre-existing small congenital melanocytic naevus. Overall 5-year survival was 81%, with a mean follow-up of 8.5 years. Ulceration and tumour thickness of greater than 1.5 mm were associated with a poor prognosis.
1967年至1993年间，布里斯托尔的弗伦奇医院诊断出3246例恶性黑色素瘤患者。本文报告了47例年龄在21岁及以下的患者，其中包括10例14岁以下的青春期前病例。除18例新病例外，这是对该中心1986年最初发表的一组病例的进一步随访。大多数（89%）病变发生在躯干和四肢，女性下肢病变居多。83%的黑色素瘤为浅表扩散型：72%侵犯至克拉克III级和IV级。厚度范围为0.29毫米至50.00毫米（中位数为1.20毫米）。17%的病例出现溃疡，32%的黑色素瘤发生在先前存在的小先天性黑素细胞痣内。总体5年生存率为81%，平均随访8.5年。溃疡和肿瘤厚度大于1.5毫米与预后不良有关。
