BDP/J小鼠逆转录病毒诱导的免疫抑制的恢复：“回归者”表型的主导地位。
Recovery from retrovirus-induced immune suppression in BDP/J mice: dominance of the "regressor' phenotype.
作者信息
Gilmore G L
机构信息
Department of Immunology, Medical Biology Institute, La Jolla, CA, USA.
出版信息
Immunology. 1997 Jan;90(1):7-13. doi: 10.1046/j.1365-2567.1997.00127.x.
Murine acquired immune deficiency syndrome (MAIDS) is an immunosuppressive disease of mice induced by infection with the LP-BM5 murine leukemia virus (MuLV) retrovirus isolate. Certain inbred strains of mice are resistant to disease, but F1 crosses between sensitive and resistant strains are predominantly sensitive to MAIDS. One inbred strain, BDP, demonstrates a novel disease phenotype, recovery of immune function after a period of profound immune suppression. This trait is genetically dominant in crosses between BDP and either sensitive or resistant strains. The 'regressor' phenotype reveals the existence of a mechanism for recovery from immunosuppressive retrovirus infections, which may be of import in developing therapies for AIDS patients.
小鼠获得性免疫缺陷综合征（MAIDS）是一种由感染LP - BM5小鼠白血病病毒（MuLV）逆转录病毒分离株诱导的小鼠免疫抑制疾病。某些近交系小鼠对该疾病具有抗性，但敏感和抗性品系之间的F1杂交后代对MAIDS大多敏感。一个近交系BDP表现出一种新的疾病表型，即在经历一段深度免疫抑制后免疫功能恢复。这一特性在BDP与敏感或抗性品系的杂交中具有遗传显性。“回归者”表型揭示了从免疫抑制性逆转录病毒感染中恢复的机制的存在，这可能对开发艾滋病患者的治疗方法具有重要意义。
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