Sechler J M, Lawler A, Hartley J W, Morse H C, McCarty T C, Swofford R, Rosenberg A S
Division of Hematologic Products, Food and Drug Administration, Bethesda, Maryland 20892, USA.
J Exp Med. 1996 Dec 1;184(6):2101-8. doi: 10.1084/jem.184.6.2101.
To examine whether a retroviral disease can be controlled in animals in which cells from a resistant strain coexist in a state of immunological tolerance with cells from a susceptible strain, allophenic mice were constructed and infected with LP-BM5 murine leukemia viruses which induce a fatal disorder, termed murine acquired immunodeficiency syndrome (MAIDS), characterized by lymphoproliferation and immunodeficiency in susceptible inbred strains of mice. We found that in two different strain combinations, resistance to MAIDS was contingent on the presence in individual animals of >50% of lymphocytes of resistant strain origin and correlated with reduction or elimination of retrovirus. In contrast, animals harboring substantial, but less than predominant, numbers of genetically resistant lymphocytes developed disease and died within the same time frame as susceptible control mice with uncontained proliferation of retrovirus.
为了研究在来自抗性品系的细胞与来自易感品系的细胞以免疫耐受状态共存的动物中，逆转录病毒疾病是否能够得到控制，我们构建了异表型小鼠，并使其感染LP - BM5鼠白血病病毒，该病毒可诱发一种致命疾病，称为鼠获得性免疫缺陷综合征（MAIDS），其特征为易感近交系小鼠出现淋巴细胞增殖和免疫缺陷。我们发现，在两种不同的品系组合中，对MAIDS的抗性取决于个体动物中起源于抗性品系的淋巴细胞比例是否超过50%，并且与逆转录病毒的减少或消除相关。相比之下，携带大量但未占主导数量的遗传抗性淋巴细胞的动物发生了疾病，并在与易感对照小鼠相同的时间范围内死亡，且逆转录病毒呈不受控制的增殖状态。
