Endresen L P
Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.
J Theor Biol. 1997 Jan 7;184(1):41-50. doi: 10.1006/jtbi.1996.0240.
A model of the rabbit sinoatrial action potential is introduced, based on a model by Morris & Lecar. One cell is described by two nonlinear first-order ordinary differential equations, with ten constant parameters. The model is much simpler than most other models in use, but can reproduce perfectly experimentally recorded action potentials. The dynamics of two coupled cells, with and without the presence of periodic acetylcholine pulses, shows examples of bifurcations and strange attractors, mathematical phenomena characterizing chaotic motion. It remains to be clarified whether such dynamics is actually observed, for example in the small irregular variations of the normal heart rate.
基于莫里斯和勒卡尔的模型，引入了一种兔窦房动作电位模型。一个细胞由两个非线性一阶常微分方程描述，有十个常数参数。该模型比大多数其他正在使用的模型要简单得多，但能完美再现实验记录的动作电位。两个耦合细胞在有和没有周期性乙酰胆碱脉冲情况下的动力学，展示了分岔和奇怪吸引子的例子，这些数学现象是混沌运动的特征。例如在正常心率的微小不规则变化中，这种动力学是否实际被观察到仍有待阐明。
