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How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.
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OpenCMISS: a multi-physics & multi-scale computational infrastructure for the VPH/Physiome project.
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Cardiac cell modelling: observations from the heart of the cardiac physiome project.
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Molecular determinants of channel function.
Physiol Rev. 1992 Oct;72(4 Suppl):S89-158. doi: 10.1152/physrev.1992.72.suppl_4.S89.
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New studies of the excitatory sodium currents in heart muscle.
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Fifty years of the Hodgkin-Huxley era.
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The Hodgkin-Huxley Na+ channel model versus the five-state Markovian model.
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An Understandable, Extensible, and Reusable Implementation of the Hodgkin-Huxley Equations Using Modelica.
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Resolving Artifacts in Voltage-Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings.
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Guidelines for mechanistic modeling and analysis in cardiovascular research.
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Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar.
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Models of the cardiac L-type calcium current: A quantitative review.
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Pacemaking function of two simplified cell models.
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Bifurcations and Proarrhythmic Behaviors in Cardiac Electrical Excitations.
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Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.
Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1023-30. doi: 10.1152/ajpheart.00785.2011. Epub 2011 Dec 9.
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A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions.
Philos Trans A Math Phys Eng Sci. 2011 Nov 13;369(1954):4205-32. doi: 10.1098/rsta.2011.0127.
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Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation.
Circ Res. 2011 Oct 14;109(9):1055-66. doi: 10.1161/CIRCRESAHA.111.253955. Epub 2011 Sep 15.
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Virtual tissue engineering of the human atrium: modelling pharmacological actions on atrial arrhythmogenesis.
Eur J Pharm Sci. 2012 Jul 16;46(4):209-21. doi: 10.1016/j.ejps.2011.08.014. Epub 2011 Aug 24.
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Successes and failures in modeling heart cell electrophysiology.
Heart Rhythm. 2011 Nov;8(11):1798-803. doi: 10.1016/j.hrthm.2011.06.014. Epub 2011 Jun 16.
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Ca²⁺-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2²⁺ affirming that increasing SERCA reduces aftercontractions.
Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H921-35. doi: 10.1152/ajpheart.01055.2010. Epub 2011 Jun 10.
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Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient.
J Mol Cell Cardiol. 2011 May;50(5):863-71. doi: 10.1016/j.yjmcc.2011.02.007. Epub 2011 Feb 21.
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Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers.
Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1806-13. doi: 10.1152/ajpheart.01170.2010. Epub 2011 Feb 18.
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A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform.
Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1045-63. doi: 10.1152/ajpheart.00219.2010. Epub 2010 Jul 23.

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