霍奇金-赫胥黎方程如何启发了心脏物理模型项目。
How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.
机构信息
Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.
出版信息
J Physiol. 2012 Jun 1;590(11):2613-28. doi: 10.1113/jphysiol.2011.224238. Epub 2012 Apr 2.
Abstract
Early modelling of cardiac cells (1960-1980) was based on extensions of the Hodgkin-Huxley nerve axon equations with additional channels incorporated, but after 1980 it became clear that processes other than ion channel gating were also critical in generating electrical activity. This article reviews the development of models representing almost all cell types in the heart, many different species, and the software tools that have been created to facilitate the cardiac Physiome Project.
摘要
早期的心脏细胞建模（1960-1980 年）是基于 Hodgkin-Huxley 神经轴突方程的扩展，并纳入了其他通道，但 1980 年后，人们清楚地认识到，除了离子通道门控之外，其他过程对于产生电活动也很重要。本文回顾了代表心脏中几乎所有细胞类型、许多不同物种的模型的发展，以及为促进心脏生理模型项目而创建的软件工具。
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