Wang J J, Li J K, Drzewiecki G
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08855-0909, USA.
Med Biol Eng Comput. 1996 Nov;34(6):477-80. doi: 10.1007/BF02523854.
Left ventricular (LV) function due to two concurrent ischaemic zones (IZs) is investigated using a cardiovascular system model. The model comprises a three-compartment LV, the venous return and the arterial system. Haemodynamic responses of the LV to changes in the IZ size and myocardial contraction timings are explored. Results show that the greater the degree of asynschonisation is between the normal zone and the IZ, and the larger the ischaemic size, the more severe the LV dysfunction. Pre-load augmentation improves LV function. Model-predicted features are consistent with reported observations associated with myocardial ischaemia. The extent of the usefulness and limitations of this model is also discussed.
使用心血管系统模型研究了由两个并发缺血区（IZs）导致的左心室（LV）功能。该模型包括一个三室左心室、静脉回流和动脉系统。探讨了左心室对缺血区大小和心肌收缩时间变化的血流动力学反应。结果表明，正常区和缺血区之间的不同步程度越大，缺血面积越大，左心室功能障碍就越严重。增加前负荷可改善左心室功能。模型预测的特征与报道的与心肌缺血相关的观察结果一致。还讨论了该模型的有用性和局限性。
