Gorelick P B
Department of Neurologic Sciences, Rush Medical Center, Chicago, IL 60612, USA.
Stroke. 1997 Feb;28(2):459-63. doi: 10.1161/01.str.28.2.459.
Cognitive impairment associated with vascular disease may be the only preventable form of dementia of late life. Identification of risk factors for dementia associated with stroke may be a prelude to improved intervention.
I reviewed putative risk factors for dementia associated with stroke. These included demographic, atherogenic, stroke-related, and genetic factors. Key studies from the English literature were reviewed and graded according to quality of evidence ratings (classes I, II, and III). Although many of the cardiovascular disease risk factors are logical antecedents of dementia associated with stroke, age was the only factor that could be considered a well-documented risk factor.
We should continue to support efforts directed at primary stroke prevention and the brain-at-risk and predementia stages. Additional rigorous epidemiological study is needed to clarify risk factors for dementia associated with stroke.
与血管疾病相关的认知障碍可能是晚年痴呆唯一可预防的形式。识别与中风相关的痴呆风险因素可能是改善干预措施的前奏。
我回顾了与中风相关的痴呆的假定风险因素。这些因素包括人口统计学、动脉粥样硬化、中风相关和遗传因素。对英文文献中的关键研究进行了回顾，并根据证据质量等级（I、II和III类）进行了分级。尽管许多心血管疾病风险因素在逻辑上是与中风相关的痴呆的先行因素，但年龄是唯一可被视为有充分文献记载的风险因素。
我们应继续支持针对原发性中风预防以及处于脑部风险和痴呆前期阶段的努力。需要进行更多严格的流行病学研究以阐明与中风相关的痴呆的风险因素。
