Van Beers B E, Goudemant J F, Oksendal A, Jamart J, Delos M, Thiran J P, Demeure R, Pringot J, Maldague B
Department of Radiology, Université Catholique de Louvain, St-Luc University Hospital, Brussels, Belgium.
Acad Radiol. 1997 Jan;4(1):35-42. doi: 10.1016/s1076-6332(97)80159-6.
The authors assessed whether the small-molecular-weight magnetic resonance (MR) imaging contrast agents dysprosium diethylenetriamepentaacetic acid bismethylamide (sprodiamide injection), which enhances T2*, and gadolinium diethylenetriamepentaacetic acid bismethylamide (gadodiamide injection), which enhances T1, could improve the detection of reperfused ischemia of the rat intestine.
Eighteen rats were subjected to vascular occlusion of the distal ileum for 30 minutes, followed by reperfusion. Ten minutes after reperfusion, T1- and T2-weighted spin-echo (SE) images were obtained before and after administration of sprodiamide, gadodiamide, or both. The same imaging protocol was applied in another group of 18 rats subjected to 10 minutes of occlusion and reperfusion. Histologic examination of the intestine was performed after MR imaging.
Villous injury (ie, denudation) was observed in most cases after 30 minutes of occlusion, but not after 10 minutes of occlusion. After 30 minutes of occlusion, the superficial part of the ischemic intestine was hyperintense to the normal intestine on unenhanced T2-weighted images. Administration of sprodiamide improved the contrast between the normal and ischemic intestine on T2-weighted images, and administration of both gadodiamide and sprodiamide improved the contrast on T1- and T2-weighted images. After 10 minutes of occlusion, no contrast was discernible before or after contrast material administration.
These results suggest that the detection of reperfused intestinal ischemia of sufficient duration to cause villous injury can be improved by using sprodiamide injection alone or in combination with gadodiamide.
作者评估了小分子磁共振（MR）成像造影剂二乙三胺五乙酸钆双甲酰胺（喷替酸钆注射剂）（可增强T2*）和钆双胺（钆喷酸葡胺注射剂）（可增强T1）是否能改善大鼠肠道再灌注缺血的检测。
18只大鼠接受回肠末端血管闭塞30分钟，随后进行再灌注。再灌注10分钟后，在注射喷替酸钆、钆双胺或两者之前和之后获取T1加权和T2加权自旋回波（SE）图像。另一组18只大鼠接受10分钟的闭塞和再灌注，应用相同的成像方案。MR成像后对肠道进行组织学检查。
在大多数情况下，闭塞30分钟后观察到绒毛损伤（即剥脱），但闭塞10分钟后未观察到。闭塞30分钟后，在未增强的T2加权图像上，缺血肠段的表层相对于正常肠段呈高信号。注射喷替酸钆改善了T2加权图像上正常肠段与缺血肠段之间的对比度，同时注射钆双胺和喷替酸钆改善了T1加权和T2加权图像上的对比度。闭塞10分钟后，注射造影剂前后均未观察到对比度差异。
这些结果表明，单独使用喷替酸钆注射剂或与钆双胺联合使用，可以改善对足以导致绒毛损伤的再灌注肠道缺血的检测。
