Lewis D M, Bradwell A R, Shore A C, Beaman M, Tooke J E
Department of Vascular Medicine, Royal Devon and Exeter Hospital, UK.
Eur J Clin Invest. 1997 Jan;27(1):64-8. doi: 10.1046/j.1365-2362.1997.740627.x.
Rapid ascent to altitude risks the development of acute mountain sickness. This study demonstrates changes in peripheral capillary filtration coefficient and renal protein loss in subjects suffering from various degrees of mountain sickness after passive ascent to 4559 m. Capillary filtration coefficient of the calf capillary bed, measured by computer-based multistep strain gauge plethysmography, increased significantly after 23.5 h at altitude when symptoms were most severe: 4.45 (2.76-6.03) to 6.31 (3.86-11.07) ml min(-1) per 100 g of tissue mmHg(-1), median (range) (P < 0.02). Urinary albumin excretion was increased after one night at altitude from 1.1 (0.6-1.5) to 2.45 (1.0-6-8) mg of albumin per mmol of creatinine (P < 0.05). These results demonstrate simultaneous leakage of a peripheral capillary bed to fluid measured by strain gauge plethysmography, and renal albumin leak, and suggest a systemic process of increased capillary leakage for different-sized molecules caused by rapid exposure to hypobaric hypoxia.
快速上升到高原会有患急性高原病的风险。本研究显示了被动上升到4559米后，患有不同程度高原病的受试者外周毛细血管滤过系数和肾脏蛋白质流失的变化。通过基于计算机的多步应变片体积描记法测量的小腿毛细血管床的毛细血管滤过系数，在海拔23.5小时症状最严重时显著增加：从4.45（2.76 - 6.03）增加到6.31（3.86 - 11.07）毫升·分钟⁻¹·每100克组织·毫米汞柱⁻¹，中位数（范围）（P < 0.02）。在海拔停留一晚后，尿白蛋白排泄量从每毫摩尔肌酐1.1（0.6 - 1.5）毫克白蛋白增加到2.45（1.0 - 6.8）毫克白蛋白（P < 0.05）。这些结果表明，通过应变片体积描记法测量的外周毛细血管床同时向液体渗漏，以及肾脏白蛋白渗漏，并提示快速暴露于低压缺氧会导致不同大小分子的毛细血管渗漏增加的全身性过程。
