Neumann C J, Cohen S M
European Molecular Biology Laboratory, Heidelberg, Germany.
Development. 1997 Feb;124(4):871-80. doi: 10.1242/dev.124.4.871.
Short-range interaction between dorsal and ventral (D and V) cells establishes an organizing center at the DV compartment boundary that controls growth and specifies cell fate along the dorsal-ventral axis of the Drosophila wing. The secreted signaling molecule Wingless (Wg) is expressed by cells at the DV compartment boundary and has been implicated in mediating its long-range patterning activities. Here we show that Wg acts directly, at long range, to define the expression domains of its target genes, Distal-less and vestigial. Expression of the Achaete-scute genes, Distal-less and vestigial at different distances from the DV boundary is controlled by Wg in a concentration-dependent manner. We propose that Wg acts as a morphogen in patterning the D/V axis of the wing.
背侧和腹侧（D和V）细胞之间的短程相互作用在背腹区室边界处建立了一个组织中心，该中心控制果蝇翅膀背腹轴上的生长并指定细胞命运。分泌的信号分子无翅（Wg）由背腹区室边界处的细胞表达，并参与介导其远程模式形成活动。在这里，我们表明Wg在远距离直接作用，以定义其靶基因Distal-less和vestigial的表达域。Achaete-scute基因、Distal-less和vestigial在距背腹边界不同距离处的表达由Wg以浓度依赖的方式控制。我们提出Wg在翅膀背/腹轴的模式形成中充当形态发生素。
