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蝶翅斑纹发育过程中 Wnt 信号通路成员的时空调控。

Spatial and temporal regulation of Wnt signaling pathway members in the development of butterfly wing patterns.

机构信息

Department of Biological Sciences, National University of Singapore, Singapore - 117557.

Science Division, Yale-NUS College, Singapore - 138527.

出版信息

Sci Adv. 2023 Jul 28;9(30):eadg3877. doi: 10.1126/sciadv.adg3877. Epub 2023 Jul 26.

DOI:10.1126/sciadv.adg3877
PMID:37494447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10371022/
Abstract

Wnt signaling members are involved in the differentiation of cells associated with eyespot and band color patterns on the wings of butterflies, but the identity and spatio-temporal regulation of specific Wnt pathway members remains unclear. Here, we explore the localization and function of Armadillo/β-catenin dependent (canonical) and Armadillo/β-catenin independent (noncanonical) Wnt signaling in eyespot and band development in by localizing Armadillo (Arm), the expression of all eight ligand and four receptor transcripts present in the genome of this species and testing the function of some of the ligands and receptors using CRISPR-Cas9. We show that distinct Wnt signaling pathways are essential for eyespot and band patterning in butterflies and are likely interacting to control their active domains.

摘要

Wnt 信号成员参与与蝴蝶翅膀上眼斑和带色图案相关的细胞分化，但特定 Wnt 途径成员的身份和时空调节仍不清楚。在这里，我们通过定位 Armadillo/β-catenin 依赖性（经典）和 Armadillo/β-catenin 独立性（非经典）Wnt 信号在眼睛斑点和带发育中的作用，探索了在这种物种的基因组中存在的所有八个 配体和四个 受体转录本的表达，并用 CRISPR-Cas9 测试了一些配体和受体的功能。我们表明，不同的 Wnt 信号通路对于蝴蝶的眼斑和带图案形成是必不可少的，并且可能相互作用以控制它们的活性域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cef/10371022/41cfb8960865/sciadv.adg3877-f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cef/10371022/41cfb8960865/sciadv.adg3877-f10.jpg
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