Nanashima A, Tagawa Y, Yasutake T, Fujise N, Kashima K, Nakagoe T, Ayabe H
First Department of Surgery, Nagasaki University School of Medicine, Japan.
Cancer Detect Prev. 1997;21(1):7-11.
The deletion of chromosome 11q is observed frequently in tumors of the large intestine. To investigate the relationship between aberrations of chromosome 11 and histopathological features of colorectal carcinoma, we examined the frequency of chromosome aberrations using fluorescence in situ hybridization to 29 short-term cultured cells from surgical specimens. Numerical aberrations were not related to any factors. The deletion of chromosome 11 was frequently observed in larger (> or = 5 cm) and more invasive tumors (> or = T3 category) (p < 0.05). Furthermore, the incidence of aberrations tended to increase in Dukes' B. Although translocation of chromosome 11 was also found in 17% of cases, it was not associated with histopathological features. Our findings indicate that the deletion of chromosome 11 is closely related to the progression of colorectal carcinoma.
在大肠肿瘤中经常观察到11号染色体缺失。为了研究11号染色体畸变与结肠直肠癌组织病理学特征之间的关系，我们使用荧光原位杂交技术检测了29份手术标本短期培养细胞中的染色体畸变频率。数量畸变与任何因素均无关联。在较大（≥5 cm）且侵袭性更强（≥T3期）的肿瘤中经常观察到11号染色体缺失（p<0.05）。此外，在杜克B期畸变发生率有增加趋势。虽然在17%的病例中也发现了11号染色体易位，但它与组织病理学特征无关。我们的研究结果表明，11号染色体缺失与结肠直肠癌的进展密切相关。
