Trail M L, Zeringue G P, Chicola J P
Laryngoscope. 1977 Oct;87(10 Pt 1):1685-91. doi: 10.1288/00005537-197710000-00012.
Two cases of carcinoma arising in thyroglossal duct remnants are reported to add to the previously documented 78 cases in the literature. This rare lesion, which occurs is less than 1% of thyroglossal duct abnormalities, pathologically and clinically is similar to primary tumors arising in the thyroid gland. Papillary adenocarcinomas constitute 75-85% of all cases reported and most are confined to the duct remnant itself with metastasis being infrequently recorded. Therapy consists of wide excision of the tumor-bearing tissue (Sistrunk procedure) in those cases localized to the duct remnant itself. In instances where metastasis or additional lesions are detected in the thyroid gland, thyroid ablation and neck dissections are indicated. Additional modalities such as suppressive thyroid therapy, radioactive iodine, and external radiation have been employed. Distant metastasis is rare and the long-term prognosis is very favorable.
本文报告了2例起源于甲状舌管残余的癌，以补充文献中先前记录的78例病例。这种罕见病变在甲状舌管异常中发生率不到1%，在病理和临床上与起源于甲状腺的原发性肿瘤相似。乳头状腺癌占所有报告病例的75 - 85%，大多数局限于导管残余本身，很少有转移记录。对于局限于导管残余本身的病例，治疗方法是广泛切除含肿瘤组织（Sistrunk手术）。如果在甲状腺中检测到转移或其他病变，则需进行甲状腺切除和颈部清扫。还采用了其他治疗方式，如甲状腺抑制治疗、放射性碘和外照射。远处转移很少见，长期预后非常良好。
