Biesenbach G, Kaiser W, Zazgornik J
Second Department of Medicine, General Hospital Linz, Austria.
Ren Fail. 1997 Jan;19(1):69-75. doi: 10.3109/08860229709026261.
Two hundred eleven patients with acute ischemic stroke, stage III or IV, received daily intravenous infusion of 500-1000 mL low-molecular dextran (dextran 40) over a period of 4 days. In 10 cases (4.7%) acute renal failure, associated with dextran infusion, could be observed; oligoanuria occurred after a mean time of 4 (3-6) days. The incidence of dextran-induced acute renal failure was significantly higher in patients with a preexisting reduction of glomerular filtration rate below 30 mL/min/1.73 m2 (p < 0.005). Five of the patients (50%) with acute renal failure died within 4-12 days after the hemodilution therapy with dextran 40; this high lethality was due to nonrenal complications.
211例处于Ⅲ期或Ⅳ期的急性缺血性脑卒中患者接受了为期4天的每日500 - 1000 mL低分子右旋糖酐（右旋糖酐40）静脉输注。在10例（4.7%）患者中观察到与右旋糖酐输注相关的急性肾衰竭；少尿在平均4（3 - 6）天后出现。肾小球滤过率预先降低至低于30 mL/min/1.73 m²的患者中，右旋糖酐诱导的急性肾衰竭发生率显著更高（p < 0.005）。5例急性肾衰竭患者（50%）在接受右旋糖酐40血液稀释治疗后的4 - 12天内死亡；这种高致死率是由非肾脏并发症导致的。
