Fickers M, Theunissen P, van Noord J A
Department of Respiratory Diseases, De Wever Hospital, Heerlen, The Netherlands.
Respiration. 1997;64(1):114-7. doi: 10.1159/000196654.
We report a case of interstitial lung disease developing during treatment with chlorambucil, vinblastine, procarbazine and prednisone for extrapulmonary Hodgkin's disease. Transbronchial biopsies demonstrated noncaseating epithelioid cell granulomata, and bronchoalveolar lavage fluid showed an increased percentage of lymphocytes, with a raised T cell helper-suppressor ratio, suggesting a diagnosis of sarcoidosis. Treatment with corticosteroids brought about complete resolution of the radiographic lesions. A possible relationship between sarcoidosis and lymphoma is discussed, and a short review of the literature is given. This case report has some unique features that, to our knowledge, have not been published before.
我们报告一例在用苯丁酸氮芥、长春碱、丙卡巴肼和泼尼松治疗肺外霍奇金病期间发生间质性肺病的病例。经支气管活检显示非干酪样上皮样细胞肉芽肿，支气管肺泡灌洗 fluid 显示淋巴细胞百分比增加，T 细胞辅助抑制比值升高，提示结节病诊断。皮质类固醇治疗使影像学病变完全消退。讨论了结节病与淋巴瘤之间的可能关系，并对文献进行了简要回顾。据我们所知，本病例报告有一些以前未发表过的独特特征。
