Ballestero S, Escobar H, Suárez L, Baquero F
Unidad de Fibrosis Quística, Hospital Ramón y Cajal, Madrid.
Enferm Infecc Microbiol Clin. 1996 Apr;14(4):245-9.
A 5-year study in patients with cystic fibrosis was carried out in order to gain a better understanding of the microbiological factors influencing clinical status and evolution.
Fifty-two patients were evaluated (mean age 16.6 years, range 0-36) during a 5 years-period (July 1988- July 1992). The clinical score of Shwachman and pulmonary function were evaluated at the beginning and at the end of the study period. Quantitative bacterial cultures were performed every 3 weeks recording the different colonical morphotypes of Pseudomonas aeruginosa.
Beside the expected results regarding the prevalence of P. aeruginosa (80.7%) and Staphylococcus aureus (65.5%), a low rate of chronic infection with Burkholderia cepacia (1.9%) and high with S. maltophilia (9.6%) was found and it is worth noting the presence of Salmonella spp. in 3 patients. Microbial colonization followed the classical age-related sequence with 53.8% of patients older than 10 colonized with mucoid strains of P. aeruginosa. Colonization with mucoid Pseudomonas, increase in sputum bacterial counts and high diversity in colonizing morphotypes were parameters related with reduced clinical scores.
The sequential study of the bacterial colonization in cystic fibrosis is important to follow the prognosis and evolution of the disease, and therefore, to choose the most effective therapy.
开展了一项针对囊性纤维化患者的为期5年的研究，以更好地了解影响临床状况和病情发展的微生物学因素。
在5年期间（1988年7月至1992年7月）对52例患者进行了评估（平均年龄16.6岁，范围0至36岁）。在研究期开始和结束时评估了Shwachman临床评分和肺功能。每3周进行一次定量细菌培养，记录铜绿假单胞菌的不同菌落形态类型。
除了关于铜绿假单胞菌（80.7%）和金黄色葡萄球菌（65.5%）流行率的预期结果外，还发现洋葱伯克霍尔德菌慢性感染率较低（1.9%），嗜麦芽窄食单胞菌感染率较高（9.6%），值得注意的是3例患者存在沙门氏菌属。微生物定植遵循经典的与年龄相关的顺序，10岁以上患者中有53.8%被铜绿假单胞菌黏液型菌株定植。黏液型铜绿假单胞菌定植、痰液细菌计数增加和定植形态类型高度多样化是与临床评分降低相关的参数。
对囊性纤维化患者细菌定植进行序贯研究对于跟踪疾病的预后和发展很重要，因此对于选择最有效的治疗方法也很重要。
