Asensi V, Carton J A, Maradona J A, Arribas J M
Departamento de Medicina Interna, Hospital Central de Asturias, Universidad de Oviedo.
Enferm Infecc Microbiol Clin. 1996 Apr;14(4):250-4.
Orbital cellulitis can produce severe neuromeningeal infections. Modern antimicrobial agents such as imipenem can be a valid therapeutical choice.
Patients with severe or complicated orbital cellulitis admitted to our hospital from 1986 through 1994 were retrospectively studied.
Nine patients with severe orbital cellulitis, seven of them older than 14 years, are reported. Cellulitis was secondary to different forms of sinusitis in five of them. The incriminated microorganisms were: Streptococcus viridans alone or combined to gram negative bacilli (3 cases), Prevotella melaninogenica and other anaerobes (2 cases), Enterococcus faecalis and Staphylococcus aureus (one case each). Three patients developed brain abscesses, one an acute bacterial meningitis and another a subdural empyema. Eight patients underwent a surgical drainage. Seven patients were treated with IV imipenem at doses of 2-3 g/day with complete cure of the orbital cellulitis and of the associated infectious complications and no secondary effects. Two patients died.
Imipenem is an effective antibiotic in the combined medical-surgical treatment of the severe or complicated orbital cellulitis.
眼眶蜂窝织炎可引发严重的神经脑膜感染。现代抗菌药物如亚胺培南可作为一种有效的治疗选择。
对1986年至1994年期间我院收治的重度或复杂性眼眶蜂窝织炎患者进行回顾性研究。
报告了9例重度眼眶蜂窝织炎患者，其中7例年龄超过14岁。5例患者的蜂窝织炎继发于不同形式的鼻窦炎。致病微生物为：单独的草绿色链球菌或与革兰氏阴性杆菌合并（3例），产黑色素普雷沃菌和其他厌氧菌（2例），粪肠球菌和金黄色葡萄球菌（各1例）。3例患者发生脑脓肿，1例发生急性细菌性脑膜炎，另1例发生硬膜下积脓。8例患者接受了手术引流。7例患者接受静脉注射亚胺培南治疗，剂量为每日2 - 3克，眼眶蜂窝织炎及相关感染并发症完全治愈，且无继发效应。2例患者死亡。
亚胺培南是重度或复杂性眼眶蜂窝织炎综合内科及外科治疗中的一种有效抗生素。
