[The effect of macromolecular adhesion factors on hepatocyte proliferation in organ cultures of mouse embryonic liver].

The use of macromolecular adhesion factors (MAF) as a molecular tool made it possible to establish that at least two molecular mechanisms of cell adhesion are violated in the livers of mice genetically predisposed to spontaneous hepatoblastomogenesis in the late embryonic stages and during the early postnatal period. The biological effect of MAF on the adhesion properties of embryonic hepatocytes correlated with their influence on cell proliferation. It has been proposed that violation of the molecular mechanisms of cell adhesion is the key moment in spontaneous blastomogenesis.