Kolesnichenko T S, Gor'kova T G
Biull Eksp Biol Med. 1985 Mar;99(3):332-4.
Linear differences were discovered in the quantitative ratio and proliferative activity of the cells of the epithelium and mesenchyma of organ cultures of the normal embryonal pulmonary tissue of mice resistant (C57BL) and predisposed (A) to lung blastomogenesis. In A mouse embryos, the index of the cell labels of the bronchiolar epithelium and fibroblast-like cells of the mesenchyma which migrate on the surface of the membrane filter was several times higher than that in C57BL mice. The number of the mesenchymal cells capable of migration in A mouse explants was essentially greater, that of the mesenchymal cells being in a direct contact with the epithelium of alveoloid and bronchiolar structures was, on the contrary, lower than in C57BL mouse explants. It is suggested that the differences described, particularly epithelial-mesenchymal interactions, are of importance for realization of the genetically determined sensitivity of these mice to spontaneous and induced lung blastomogenesis, which manifests as early as during prenatal ontogenesis.
在对肺母细胞瘤发生具有抗性（C57BL）和易感性（A）的小鼠正常胚胎肺组织器官培养物的上皮和间充质细胞的定量比率和增殖活性方面发现了线性差异。在A品系小鼠胚胎中，迁移到膜滤器表面的细支气管上皮细胞和间充质中成纤维细胞样细胞的细胞标记指数比C57BL品系小鼠高几倍。在A品系小鼠外植体中能够迁移的间充质细胞数量实质上更多，相反，与肺泡样和细支气管结构上皮直接接触的间充质细胞数量比C57BL品系小鼠外植体中的要少。有人提出，所描述的这些差异，特别是上皮-间充质相互作用，对于实现这些小鼠对自发和诱导性肺母细胞瘤发生的遗传决定敏感性很重要，这种敏感性早在产前个体发育期间就已表现出来。
