Specificity of antipyrogenic immunity.

The specificity of antipyrogenic immunity as well as the structural differences of the Enterobacteria responsible for pyrogenicity have been studied. Strains S. minnesota Re 595 and S. typhimurium SL 1102 as well as glycolipids obtained from them, further E. coli 083 and E. coli F 576 as well as the LPS extracted from them were used in the experiments. In conformity with the results of chemical analysis it was found that the method reflected exactly the antigenicity of the receptors responsible for pyrogenicity. Alterations of the antipyrogenic immunity may indicate that the structure of the single endotoxins responsible for pyrogenicity are different in antigenicity.