Matsui K, Arai T
Department of Microbiology, Meiji College of Pharmacy, Tokyo, Japan.
Microbiologica. 1991 Apr;14(2):103-12.
The specificity of protective immunity against Salmonella typhimurium in mice immunized with porins from S. typhimurium, Salmonella enteritidis and Escherichia coli was studied. High levels of protection against S. typhimurium-infection were achieved in mice immunized with porins from S. typhimurium but not from S. enteritidis and E. coli. However, our serological studies demonstrated that porins from S. typhimurium, S. enteritidis and E. coli had antigenic cross-reactivity with each another; in particular, porins immunized with porins from S. typhimurium but not from S. enteritidis or E. coli exhibited the most significant levels of delayed type hypersensitivity reaction, interleukin-2 production and interferon-gamma production when they were elicited with whole cells of S. typhimurium. These observations suggested that the high levels of protection obtained by porin-immunization resulted from the induction of serovar specific cell-mediated immunity.
研究了用鼠伤寒沙门氏菌、肠炎沙门氏菌和大肠杆菌的孔蛋白免疫的小鼠对鼠伤寒沙门氏菌的保护性免疫特异性。用鼠伤寒沙门氏菌的孔蛋白免疫的小鼠对鼠伤寒沙门氏菌感染具有高水平的保护作用，但用肠炎沙门氏菌和大肠杆菌的孔蛋白免疫的小鼠则没有。然而，我们的血清学研究表明，鼠伤寒沙门氏菌、肠炎沙门氏菌和大肠杆菌的孔蛋白彼此之间具有抗原交叉反应性；特别是，用鼠伤寒沙门氏菌的孔蛋白免疫但未用肠炎沙门氏菌或大肠杆菌的孔蛋白免疫的小鼠，在用鼠伤寒沙门氏菌全细胞激发时，表现出最显著水平的迟发型超敏反应、白细胞介素-2产生和干扰素-γ产生。这些观察结果表明，通过孔蛋白免疫获得的高水平保护是由血清型特异性细胞介导免疫的诱导所致。
