Zielonka T M, Dobrzyński P, Pogorzelski R
Kliniki Pneumonologii AM w Warszawie.
Otolaryngol Pol. 1996;50(2):189-93.
We describe a 3 patients with Wegener's granulomatosis in remission while taking cyclophosphamide and prednisone who developed upper airway obstruction. The diagnosis was confirmed by parotid gland, pharynx, kidney biopsy. The stenosis developed in the area of previously noted tracheal ulceration and responded satisfactorily to bronchoscopic dilatation. Tracheotomy for progressive upper airway obstruction has remained the mainstay of treatment and was necessary in one of cases. We presented the others techniques of treatment subglottic stenosis-the surgical intervention and carbon dioxide laser photoresection. No antineutrophil cytoplasmic antibodies were found in the patients serum. These antibodies are of auxiliary value in recognizing Wegener's granulomatosis as well as in monitoring the activity of the disease process.
我们描述了3例在服用环磷酰胺和泼尼松处于缓解期的韦格纳肉芽肿患者,他们出现了上气道梗阻。通过腮腺、咽部、肾脏活检确诊。狭窄发生在先前发现的气管溃疡区域,经支气管镜扩张治疗效果满意。对于进行性上气道梗阻,气管切开术一直是主要治疗方法,其中1例患者有必要进行气管切开术。我们还介绍了声门下狭窄的其他治疗技术——手术干预和二氧化碳激光光切除术。患者血清中未发现抗中性粒细胞胞浆抗体。这些抗体在诊断韦格纳肉芽肿以及监测疾病进程的活动方面具有辅助价值。