Mrózek K, Heinonen K, de la Chapelle A, Bloomfield C D
Division of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Semin Oncol. 1997 Feb;24(1):17-31.
Cytogenetic studies of acute myeloid leukemia (AML) have revealed that the majority of patients display acquired chromosome aberrations. Numerous recurrent karyotypic aberrations have been and continue to be discovered in AML. Cytogenetic studies have paved the way for molecular analyses that have identified genes involved in the process of leukemogenesis. Moreover, chromosome aberrations, regardless of whether they have been molecularly characterized or not, have been shown to constitute tumor markers of diagnostic and prognostic value. This review presents current information on cytogenetic findings in AML, and correlations between karyotype and clinical features and outcome of de novo AML.
急性髓系白血病（AML）的细胞遗传学研究表明，大多数患者存在获得性染色体畸变。在AML中已经发现并将继续发现许多复发性核型畸变。细胞遗传学研究为分子分析铺平了道路，分子分析已确定了参与白血病发生过程的基因。此外，无论染色体畸变是否已进行分子特征分析，它们都已被证明是具有诊断和预后价值的肿瘤标志物。本综述介绍了AML细胞遗传学研究的当前信息，以及核型与初发AML临床特征和预后之间的相关性。
