Haraf D J, Stenson K, List M, Witt M E, Weichselbaum R R, Vokes E E
Department of Radiation and Cellular Oncology, The University of Chicago, IL 60637, USA.
Semin Oncol. 1997 Feb;24(1 Suppl 2):S2-68-S2-71.
Concomitant chemotherapy and radiation in the treatment of patients with advanced head and neck cancer is under intense investigation, although the optimal regimen remains undefined. The head and neck cancer program at the University of Chicago has reported encouraging results with concomitant 5-fluorouracil, hydroxyurea, and radiation administered every other week to patients with locally advanced or recurrent disease. The feasibility of adding continuous-infusion paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) to this combination currently is being tested in a phase I trial. We present here the rationale and preliminary results of this regimen.
同步放化疗在晚期头颈癌患者治疗中的应用正在深入研究中，尽管最佳方案仍未明确。芝加哥大学的头颈癌治疗项目报告称，对局部晚期或复发性疾病患者每隔一周同步给予5-氟尿嘧啶、羟基脲和放疗，取得了令人鼓舞的结果。目前正在一项I期试验中测试在该联合方案中加入持续静脉输注紫杉醇（泰素；百时美施贵宝公司，新泽西州普林斯顿）的可行性。我们在此介绍该方案的基本原理和初步结果。
