Eiken P A
Billeddiagnostisk afdeling, Hillerød Sygehus.
Ugeskr Laeger. 1997 Jan 27;159(5):570-6.
A review of five case-control- and eight prospective studies provides evidence of a decreased risk of fractures among postmenopausal women, who currently use or ever have used hormone replacement therapy. Twenty-three randomized clinically controlled studies provide evidence that hormone replacement therapy could increase bone mass or at least give a significantly higher bone mineral content than placebo or calcium in both the axial and peripheral skeleton. This is true for 1) healthy early postmenopausal 2) normal elderly women, 3) osteoporotic women, and 4) oophorectomized women. Moreover, one of these studies of osteoporotic women showed a significant decrease in the number of compression fractures of the spine after hormone replacement therapy.
一项对5项病例对照研究和8项前瞻性研究的综述表明，目前正在使用或曾经使用过激素替代疗法的绝经后女性骨折风险降低。23项随机临床对照研究表明，激素替代疗法可增加骨量，或至少使中轴骨和外周骨的骨矿物质含量显著高于安慰剂或钙剂。这在以下人群中均成立：1）绝经早期健康女性；2）正常老年女性；3）骨质疏松症女性；4）卵巢切除术后女性。此外，其中一项针对骨质疏松症女性的研究表明，激素替代疗法后脊柱压缩性骨折的数量显著减少。
