新生大鼠肌腱转移后伤害性退缩反射的发育适应性
Developmental adaptation of rat nociceptive withdrawal reflexes after neonatal tendon transfer.
作者信息
Holmberg H, Schouenborg J, Yu Y B, Weng H R
机构信息
Department of Physiology and Neuroscience, University of Lund, S-223 62 Lund, Sweden.
出版信息
J Neurosci. 1997 Mar 15;17(6):2071-8. doi: 10.1523/JNEUROSCI.17-06-02071.1997.
Abstract
Nociceptive withdrawal reflexes (NWRs) were studied in adult rats in which the movement patterns produced by single muscles had been altered by neonatal tendon transfer. NWRs evoked by cutaneous noxious mechanical and thermal (CO2-laser) stimulation were recorded using electromyography in a decerebrate spinal preparation. The sensitivity distribution within the receptive fields of the NWRs of the extensor digitorum longus and the peronei muscles exhibited changes corresponding to the altered movement patterns. No detectable change of NWRs was found in normal muscles whose receptive fields overlapped that of the modified muscle. Furthermore, NWRs of muscles that regained an essentially normal function after neonatal tendon transfer did not differ from normal. It is proposed that a developmental experience-dependent mechanism, which takes into account the hindlimb movement pattern caused by contraction of single muscles, underlies the functionally adapted organization of adult NWRs.
摘要
在成年大鼠中研究了伤害性退缩反射（NWRs），这些大鼠单个肌肉产生的运动模式已通过新生期肌腱转移而改变。在去大脑脊髓标本中，使用肌电图记录由皮肤有害机械和热（二氧化碳激光）刺激诱发的NWRs。趾长伸肌和腓骨肌的NWRs感受野内的敏感性分布呈现出与改变的运动模式相对应的变化。在其感受野与改变的肌肉感受野重叠的正常肌肉中未发现NWRs有可检测到的变化。此外，新生期肌腱转移后恢复基本正常功能的肌肉的NWRs与正常情况无异。有人提出，一种依赖于发育经验的机制构成了成年NWRs功能适应性组织的基础，该机制考虑了单个肌肉收缩引起的后肢运动模式。
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