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1
von Willebrand factor.血管性血友病因子
J Clin Invest. 1997 Feb 15;99(4):559-64. doi: 10.1172/JCI119195.
2
Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation.血管性血友病因子的结构及其在血小板黏附和血栓形成中的作用。
Best Pract Res Clin Haematol. 2001 Jun;14(2):257-79. doi: 10.1053/beha.2001.0133.
3
Acquired abnormalities of von Willebrand factor: facts to consider in patients with unexpected bleeding.血管性血友病因子的获得性异常：意外出血患者需考虑的因素
J Lab Clin Med. 1993 Mar;121(3):377-9.
4
[Von Willebrand factor].[血管性血友病因子]
Postepy Hig Med Dosw. 1990;44(1-3):41-61.
5
Von Willebrand factor and thrombosis.血管性血友病因子与血栓形成
Ann Hematol. 2006 Jul;85(7):415-23. doi: 10.1007/s00277-006-0085-5. Epub 2006 Mar 28.
6
von Willebrand factor, integrins, and platelets: their role in cancer.血管性血友病因子、整合素与血小板：它们在癌症中的作用。
J Lab Clin Med. 1992 May;119(5):444-7.
7
Role of von Willebrand factor in platelet thrombus formation.血管性血友病因子在血小板血栓形成中的作用。
Ann Med. 2000 Dec;32 Suppl 1:2-9.
8
von Willebrand factor.血管性血友病因子
J Clin Invest. 1997 Dec 1;100(11 Suppl):S41-6.
9
Formation and destruction of primary thrombi under the influence of blood flow and von Willebrand factor analyzed by a discrete element method.通过离散元法分析血流和血管性血友病因子影响下初级血栓的形成与破坏
Biorheology. 2003;40(1-3):265-72.
10
Insolubilized von Willebrand factor and the initial events in hemostasis.不溶性血管性血友病因子与止血的起始事件
J Lab Clin Med. 1989 Jul;114(1):1-3.

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1
The Association of Elevated Factor VIII and von Willebrand Factor (vWF) Levels with SYNTAX Score in Patients with Chronic Coronary Syndrome.慢性冠状动脉综合征患者中凝血因子VIII和血管性血友病因子（vWF）水平升高与SYNTAX评分的相关性
Biomedicines. 2025 Sep 17;13(9):2284. doi: 10.3390/biomedicines13092284.
2
Electrochemical Profiling of vWFA2 for Systemic Inflammatory State Detection.用于全身炎症状态检测的vWFA2的电化学分析
ACS Meas Sci Au. 2024 Nov 4;4(6):721-728. doi: 10.1021/acsmeasuresciau.4c00060. eCollection 2024 Dec 18.
3
A case of acquired thrombotic thrombocytopenic purpura following near-drowning.一例近乎溺亡后获得性血栓性血小板减少性紫癜病例。
Clin Nephrol Case Stud. 2024 May 3;12:36-41. doi: 10.5414/CNCS111301. eCollection 2024.
4
Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation.测定静脉血栓栓塞症中 vWF、ADAMTS-13 和血栓调节蛋白-1，并将其与因子 V Leiden 突变的存在相关联。
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296231223195. doi: 10.1177/10760296231223195.
5
Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databases.利用大规模基因数据库研究血管性血友病的人群患病率及突变图谱。
NPJ Genom Med. 2023 Oct 16;8(1):31. doi: 10.1038/s41525-023-00375-8.
6
Von Willebrand factor in diagnostics and treatment of cardiovascular disease: Recent advances and prospects.血管性血友病因子在心血管疾病诊断与治疗中的应用：最新进展与展望
Front Cardiovasc Med. 2022 Dec 2;9:1038030. doi: 10.3389/fcvm.2022.1038030. eCollection 2022.
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Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions.脓毒症中的肠道微循环功能障碍：病理生理学、临床监测及治疗干预
World J Emerg Med. 2022;13(5):343-348. doi: 10.5847/wjem.j.1920-8642.2022.031.
8
von Willebrand factor promotes platelet-induced metastasis of osteosarcoma through activation of the VWF-GPIb axis.血管性血友病因子通过激活VWF-GPIb轴促进血小板诱导的骨肉瘤转移。
J Bone Oncol. 2020 Oct 8;25:100325. doi: 10.1016/j.jbo.2020.100325. eCollection 2020 Dec.
9
Occlusive thrombosis in arteries.动脉闭塞性血栓形成
APL Bioeng. 2019 Nov 19;3(4):041502. doi: 10.1063/1.5115554. eCollection 2019 Dec.
10
Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases.获得性血管性血友病综合征与心血管疾病。
J Atheroscler Thromb. 2019 Apr 1;26(4):303-314. doi: 10.5551/jat.RV17031. Epub 2019 Mar 12.

本文引用的文献

1
Shear-dependent changes in the three-dimensional structure of human von Willebrand factor.人血管性血友病因子三维结构的剪切依赖性变化。
Blood. 1996 Oct 15;88(8):2939-50.
2
Platelets and shear stress.血小板与剪切应力。
Blood. 1996 Sep 1;88(5):1525-41.
3
Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis.从人血浆中部分纯化并鉴定一种蛋白酶，该蛋白酶可将血管性血友病因子切割成体内蛋白水解产生的片段。
Blood. 1996 May 15;87(10):4223-34.
4
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.通过黏附于纤维蛋白原或在血管性血友病因子上移位来启动血小板黏附。
Cell. 1996 Jan 26;84(2):289-97. doi: 10.1016/s0092-8674(00)80983-6.
5
Localization of von Willebrand factor binding domains to endothelial extracellular matrix and to type VI collagen.血管性血友病因子结合域在内皮细胞外基质和VI型胶原中的定位。
Arterioscler Thromb. 1993 Mar;13(3):398-406. doi: 10.1161/01.atv.13.3.398.
6
von Willebrand factor.血管性血友病因子
FASEB J. 1993 Feb 1;7(2):308-16. doi: 10.1096/fasebj.7.2.8440408.
7
Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma.血小板计数升高作为血浆中血管性血友病因子多聚体分布异常的一个原因。
Blood. 1993 Sep 15;82(6):1749-57.
8
Blockade of platelet membrane glycoprotein Ib receptors delays intracoronary thrombogenesis, enhances thrombolysis, and delays coronary artery reocclusion in dogs.阻断血小板膜糖蛋白Ib受体可延缓犬冠状动脉内血栓形成，增强溶栓效果，并延缓冠状动脉再闭塞。
Circulation. 1994 Jun;89(6):2822-8. doi: 10.1161/01.cir.89.6.2822.
9
Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides.血管性血友病因子（vWF）与胶原蛋白的相互作用。通过重组vWF A结构域多肽分析确定主要胶原蛋白结合位点的定位。
J Biol Chem. 1995 May 5;270(18):10822-7. doi: 10.1074/jbc.270.18.10822.
10
Function of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras.正常猪与血管性血友病猪交叉骨髓移植后血管性血友病因子的功能：对嵌合体动脉血栓形成的影响。
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2455-9. doi: 10.1073/pnas.92.7.2455.

von Willebrand factor.

作者信息

Ruggeri Z M

机构信息

Division of Experimental Thrombosis and Hemostasis, Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

J Clin Invest. 1997 Feb 15;99(4):559-64. doi: 10.1172/JCI119195.

DOI:10.1172/JCI119195
PMID:9045854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC507834/
Abstract
摘要