单侧肾切除对大鼠膀胱致癌作用的促进效应。

Promoting effect of unilateral nephrectomy on urinary bladder carcinogenesis in rats.

作者信息

Saikawa S, Kanamaru H, Li B, Matsukawa S, Okada K

机构信息

Department of Urology, Fukui Medical School, Matsuoka.

出版信息

Jpn J Cancer Res. 1996 Nov;87(11):1121-4. doi: 10.1111/j.1349-7006.1996.tb03121.x.

DOI:10.1111/j.1349-7006.1996.tb03121.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921012/

Abstract

The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN administration significantly increased both the number and the volume of visible tumors per rat as compared with the sham-operated group. Histological examination also revealed that the numbers of papillonodular hyperplasia and cancer per basement membrane were significantly increased by unilateral nephrectomy. The results imply a growth-enhancing effect of unilateral nephrectomy on carcinogenesis of the rat bladder.

摘要

通过大体和显微镜检查，研究了单侧肾切除对用0.05% N-丁基-N-(4-羟丁基)亚硝胺（BBN）处理6周的雄性F344大鼠膀胱肿瘤生长的影响。与假手术组相比，在BBN给药开始4周后进行单侧肾切除显著增加了每只大鼠可见肿瘤的数量和体积。组织学检查还显示，单侧肾切除使每个基底膜的乳头状结节增生和癌的数量显著增加。结果表明单侧肾切除对大鼠膀胱致癌作用有生长促进作用。

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