Karmody C S, Annino D J
Department of Otolaryngology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Facial Plast Surg. 1995 Oct;11(4):251-6. doi: 10.1055/s-2008-1064541.
Malformations of the auricle are not uncommon and occur in 1 out of 12500 births. They can occur alone or can be associated with genetically determined syndromes. Most congenital malformations in the human occur during the third to twelfth weeks of embryonic life. During this period, the external ear is undergoing development and can be affected in many ways. There are three parts to the external ear: the auricle, the cartilaginous external auditory canal, and the bony external canal. The auricle (pinna) and the cartilaginous canal are closely related and probably develop from the same anlage. The bony canal is derived from the tympanic ring which is an incomplete cylinder of membranous bone. It must be clearly understood that, although this article is primarily concerned with the morphogenesis and dysmorphogenesis of the auricle, the rest of the external ear, specifically the external auditory canal, is developing simultaneously. Therefore, maldevelopment of the external canal and the auricle will frequently occur together.
耳廓畸形并不罕见,在每12500例出生中就有1例发生。它们可以单独出现,也可能与基因决定的综合征相关。人类大多数先天性畸形发生在胚胎生命的第3至12周。在此期间,外耳正在发育,可能会受到多种影响。外耳有三个部分:耳廓、软骨性外耳道和骨性外耳道。耳廓(耳郭)和软骨性外耳道密切相关,可能由同一原基发育而来。骨性外耳道源自鼓环,鼓环是一个不完全的膜性骨圆柱体。必须清楚地认识到,虽然本文主要关注耳廓的形态发生和畸形发生,但外耳的其他部分,特别是外耳道,也在同时发育。因此,外耳道和耳廓的发育异常常常会同时出现。