Wittbrodt E T
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, USA.
Arch Intern Med. 1997 Feb 24;157(4):399-408.
Myasthenia gravis is a disease of the neuromuscular junction in which normal transmission of the neuron-to-muscle impulse is impaired or prevented by acetylcholine receptor antibodies. Several classes of drugs have been associated with clinical worsening of existing myasthenia gravis, and a small subset of drugs, most notably the antirheumatic agent penicillamine, have been implicated in the pathogenesis of a variant of the disease. Recent case reports and other documented evidence link a number of specific agents with clinical worsening of myasthenia gravis.
重症肌无力是一种神经肌肉接头疾病，其中神经元到肌肉的冲动正常传递受到乙酰胆碱受体抗体的损害或阻止。几类药物与现有重症肌无力的临床恶化有关，一小部分药物，最显著的是抗风湿药青霉胺，与该疾病变体的发病机制有关。最近的病例报告和其他文献证据将许多特定药物与重症肌无力的临床恶化联系起来。
