Ogutlu Hakan, Karayagmurlu Ali, Esin Ibrahim Selcuk, Dursun Onur Burak
Department of Child and Adolescent Psychiatry, Ataturk University School of Medicine Erzurum, Turkey.
Department of Child and Adolescent Psychiatry, Gaziantep Maternity and Child Health Hospital, Gaziantep, Turkey.
Eurasian J Med. 2018 Jun;50(2):128-129. doi: 10.5152/eurasianjmed.2018.17296. Epub 2018 Jun 1.
Myasthenia gravis (MG) is an autoimmune disease, which can be triggered by anticholinergic agents. The 6-year-old female patient was admitted to the outpatient clinic. She was had been previously diagnosed with comorbid attention deficit hyperactivity disorder and conduct disorder and was receiving short-acting methylphenidate and risperidone, as recommended by a child psychiatrist. However, after using the drugs, she stated that she was overly tired during the day and that her eyelids drooped. Hence, the current treatment was stopped. She was hospitalized with a prediagnosis of ocular type MG and pyridostigmine (90 mg/day) treatment was started. The patient recovered and subsequently the treatment was stopped. Since psychiatric symptoms of the patient resurfaced, long-acting methylphenidate treatment was initiated. During this treatment, the symptoms of MG did not return. The Naranjo's scale of adverse drug reaction probability was completed. Consequently, there may be an association between risperidone and MG.
重症肌无力（MG）是一种自身免疫性疾病，可由抗胆碱能药物引发。一名6岁女性患者到门诊就诊。她之前被诊断患有注意力缺陷多动障碍和品行障碍合并症，正按照儿童精神科医生的建议服用短效哌甲酯和利培酮。然而，用药后，她说自己白天过度疲劳，且眼睑下垂。因此，停止了当前治疗。她因初步诊断为眼肌型重症肌无力住院，并开始使用吡啶斯的明（90毫克/天）治疗。患者康复后，随后停止了治疗。由于患者的精神症状再次出现，开始了长效哌甲酯治疗。在该治疗期间，重症肌无力症状未复发。完成了药物不良反应概率的纳兰霍量表评估。因此，利培酮与重症肌无力之间可能存在关联。
