Pascual M, Swinford R D, Tolkoff-Rubin N
Renal Unit, Massachusetts General Hospital, Boston, USA.
Annu Rev Med. 1997;48:467-76. doi: 10.1146/annurev.med.48.1.467.
Recent clinical studies of acute renal failure in adults have focused attention on the biocompatibility of the dialysis membrane as a possible factor influencing patient morbidity and mortality. In this article, we review the concept of dialysis membrane biocompatibility and highlight the difficulty of finding an ideal definition. We then expand on the possible roles of complement and neutrophil activation by dialysis membranes, which may prolong the recovery from acute renal failure. The results of several clinical studies analyzing the impact of dialysis membranes on the course and outcome of acute renal failure are discussed. Finally, the possible relevance of biocompatibility in continuous renal replacement therapies is emphasized.
近期针对成人急性肾衰竭的临床研究已将注意力集中在透析膜的生物相容性上，视其为可能影响患者发病率和死亡率的一个因素。在本文中，我们回顾了透析膜生物相容性的概念，并强调了寻找理想定义的困难。接着，我们详述了透析膜激活补体和中性粒细胞的可能作用，这可能会延长急性肾衰竭的恢复时间。文中还讨论了几项分析透析膜对急性肾衰竭病程和预后影响的临床研究结果。最后，强调了生物相容性在持续性肾脏替代治疗中的可能相关性。
