Swinford R D, Baid S, Pascual M
Renal Unit, Massachusetts General Hospital, Boston 02114, USA.
Am J Kidney Dis. 1997 Nov;30(5 Suppl 4):S32-7. doi: 10.1016/s0272-6386(97)90540-0.
Experimental and clinical studies have suggested that dialysis membrane biocompatibility may influence the morbidity and mortality of patients with acute renal failure. Complement activation by dialysis membranes may also prolong the recovery from acute renal failure. In this article, we review the concept of dialysis membrane adsorption, with particular attention to adsorption/inhibition of factor D, a highly specific serine protease of the alternative pathway of complement. The adsorptive properties of some dialysis membranes may be useful during continuous renal replacement therapies (CRRT) in critically ill patients.
实验和临床研究表明，透析膜的生物相容性可能会影响急性肾衰竭患者的发病率和死亡率。透析膜激活补体也可能会延长急性肾衰竭的恢复时间。在本文中，我们回顾了透析膜吸附的概念，特别关注补体替代途径中一种高度特异性的丝氨酸蛋白酶——D因子的吸附/抑制作用。某些透析膜的吸附特性在危重症患者的持续肾脏替代治疗（CRRT）中可能会有用。
