一种来自铜绿假单胞菌的无细胞疫苗：根据哈布斯分类法在血清群之间的同源和交叉保护。
An acellular vaccine from Pseudomonas aeruginosa: homologous and crossed protection between serogroups according to Habs' classification.
作者信息
Berche P, Véron M, Fermanian J, Daoulas-Lebourdelles F, Guégen A
出版信息
Ann Microbiol (Paris). 1979 Feb-Mar;130(2):179-88.
Homologous and cross-reactions were studied in 16 strains of Pseudomonas aeruginosa belonging to different O serogroups according to Habs' classification. By slide agglutination, cross-reactions were rare between the strains of two or three serogroups: O2, O5 and O16; O1 and O9; O7 and O8; O13 and O14. Experiments of cross-protection have been performed in mice inoculated with acellular vaccines prepared from the 16 studied strains. A high homologous protection was observed with all the 16 strains, which is in favour of existence of an O serogroup-specific immunity. However, it exists some cross-protective reactions between the serogroups. This cross-protection allows to reduce the numbers of strains for a polyvalent vaccine. A classification of P. aeruginosa into 8 classes of related serogroups (A to H) is proposed which could be a basis for an antigenic classification of P. aeruginosa.
根据哈布斯分类法，对16株属于不同O血清群的铜绿假单胞菌菌株进行了同源和交叉反应研究。通过玻片凝集试验，在两到三个血清群（O2、O5和O16；O1和O9；O7和O8；O13和O14）的菌株之间交叉反应很少见。已在接种了由16株研究菌株制备的无细胞疫苗的小鼠中进行了交叉保护实验。对所有16株菌株均观察到高度同源保护，这支持了O血清群特异性免疫的存在。然而，血清群之间存在一些交叉保护反应。这种交叉保护使得多价疫苗所需的菌株数量得以减少。提出了将铜绿假单胞菌分为8个相关血清群类别（A至H）的分类方法，这可能成为铜绿假单胞菌抗原分类的基础。
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