Seski J C, Abell M R, Morley G W
Obstet Gynecol. 1977 Oct;50(4):410-4.
The surgical tissues and clinical records of 54 surgically treated patients with microinvasive carcinoma of the cervix were retrospectively analyzed. Utilizing a definition that limited microinvasion to a depth of 3 mm, and excluded lymphatic and blood vascular involvement, the incidence of regional metastases in 37 patients for whom lymph nodes were available for study was 0%. Confluence of microinvasion did not imply a greater potential for metastatic spread or a worse prognosis. Lymphatic and blood vascular permeations were associated with nodal metastasis in one of four lesions which otherwise were microinvasive. Random cervical biopsy alone was inadequate for the diagnosis of microinvasion. Cone biopsy demonstrated an accuracy of 83% in diagnoses, but failed to eliminate intraepithelial or microinvasive carcinoma in 78% of the hysterectomy specimens. It is concluded that microinvasive carcinoma, as defined in this study, can be effectively treated by conservative rather than radical means.
对54例经手术治疗的宫颈微浸润癌患者的手术组织和临床记录进行了回顾性分析。采用将微浸润限定在3mm深度以内且排除淋巴和血管受累的定义，对37例有可用于研究的淋巴结的患者进行研究，区域转移发生率为0%。微浸润融合并不意味着转移扩散的可能性更大或预后更差。在4例原本为微浸润的病变中，有1例淋巴和血管浸润与淋巴结转移相关。单纯随机宫颈活检不足以诊断微浸润。锥形活检诊断准确率为83%，但在78%的子宫切除标本中未能排除上皮内癌或微浸润癌。结论是，本研究中定义的微浸润癌可以通过保守而非根治性手段得到有效治疗。
