Bohm J W, Krupp P J, Lee F Y, Batson H W
Obstet Gynecol. 1976 Jul;48(1):65-7.
A retrospective series of 69 patients indicates that the definition of a diagnosis of microinvasive cancer of the cervix should indicate a lack of blood vessel or lymphatic permeation as well as invasion of not more than 3 mm below the basement membrane. The incidence of lymph node metastases in this group of patients in whom microinvasive cancer of the cervix had been diagnosed was 7.1%. Two of the 4 patients with positive lymph nodes demonstrated lymphatic or blood vessel permeation on preoperative conization and 2 did not, an incidence of 3.6%. One patient had lymphatic invasion on conization with negative lymph nodes on final surgical specimen. Two patients had recurrent epidermoid carcinoma within less than 10 years and died of recurrent carcinoma. Maximum survival can only be achieved by full treatment of Stage IA lesions. Since surgical mortality was absent in our series, surgical extirpation by extensive (radical) hysterectomy and bilateral lymphadenectomy should give optimum results.
一项对69例患者的回顾性研究表明，宫颈微浸润癌的诊断定义应表明不存在血管或淋巴浸润，且浸润深度不超过基底膜以下3毫米。在这组被诊断为宫颈微浸润癌的患者中，淋巴结转移的发生率为7.1%。4例淋巴结阳性的患者中，2例在术前锥切时显示有淋巴或血管浸润，2例未显示，发生率为3.6%。1例患者在锥切时有淋巴浸润，但最终手术标本的淋巴结为阴性。2例患者在不到10年内出现复发性表皮样癌，并死于复发性癌。只有通过对IA期病变进行充分治疗才能实现最大生存率。由于我们的系列研究中没有手术死亡病例，广泛（根治性）子宫切除术和双侧淋巴结切除术的手术切除应能取得最佳效果。
