Hansen S H, Holck S, Flyger H, Tange U B
Department of Pathology, Hillerød Hospital, Denmark.
APMIS. 1996 Dec;104(12):891-4.
Angiosarcoma developing in unusual sites such as the gastrointestinal tract is not uncommonly associated with a known eliciting factor. Thus, among hitherto reported cases of angiosarcoma of the small bowel, five were radiation-associated. One additional example of ileal angiosarcoma induced by therapeutic irradiation of endometrial carcinoma is herein reported as a reminder of this causal association. DNA analyses of the primary growth as well as the metastatic deposits showed at least four aneuploid cell clones indicating genetic instability. This observation corresponds to the consistently poor prognosis of radiation-associated angiosarcoma of the small bowel.
发生在胃肠道等不寻常部位的血管肉瘤通常与已知的诱发因素有关。因此，在迄今报道的小肠血管肉瘤病例中，有5例与放疗相关。本文报告了1例因子宫内膜癌治疗性放疗诱发的回肠血管肉瘤，以提醒注意这种因果关系。对原发肿瘤以及转移灶的DNA分析显示至少有4个非整倍体细胞克隆，表明存在基因不稳定。这一观察结果与小肠放疗相关血管肉瘤一贯较差的预后相符。
